Each post is a discovery. IRDME is the method — the finding is the story. All results link to their pre-registered hash.
F1 pre-registered result: CHEK1 and PARP1 are the top divergers between functional proximity and genetic interaction layers in the p53/DDR network — correctly predicted from topology. The Pearson r is too low to call CONFIRMED, but the structural signal is real and the hub-identity predictions are precise.
We pre-registered 5 structural hypotheses about the p53 protein interaction network before running any analysis - then certified agreement between a curated BioGRID/DepMap dataset and STRING v12.0. All 5 confirmed. TP53, MDM2, ATM, BRCA1, and CHK2 are structurally robust across independent sources. CHEK1 and PCNA are boundary cases - hub in STRING only.
Three domains — protein networks, CPU design, and the human brain connectome — all confirm the Functional Proximity Law. Here is what the numbers say.