Each post is a discovery. IRDME is the method — the finding is the story. All results link to their pre-registered hash.
M_MED8 pre-registered experiment on Parkinson's disease as a competition rule test: dopamine depletion in substantia nigra is one of the best-confirmed mechanisms in neurology, yet UPDRS is an institutionally entrenched symptom scale structurally analogous to PANSS in schizophrenia. Which axis wins? Neither wins cleanly. The Pearson-Spearman inversion identifies two distinct institutional distortion operators: Rank-Preserving Amplification (RPA, Alzheimer's) and Magnitude-Preserving Inversion (MPI, Parkinson's). Eight experiments, three independent axes, two independently verified anomaly detections.
M_MED7 pre-registered experiment on the epilepsy evidence chain. Three mechanistically incompatible frameworks (sodium channel / channelopathy, GABA/glutamate network, autoimmune synaptopathy) coexist without paradigm islands -- the graph is connected. The seizure frequency endpoint is entrenched through convergent selection from all three frameworks. The unexpected structural finding: multi-framework convergent endpoint selection produces stronger r(justifies, selects_endpoints) = +0.490 than single-founder circular chains like antidepressants (+0.41). A new structural class is identified: convergent institutional endpoint lock-in.
M_MED6 pre-registered experiment: the statin cardiovascular evidence chain replicates the healthy topology of M_MED2 vaccines. r(justifies, selects_endpoints) = +0.676, p = 0.030. Healthy class n = 1 to n = 2. The spectrum from healthy to distorted pharmaceutical evidence chains is now anchored at both ends with statistically significant cases. No citation anomaly detected -- supporting the hypothesis that citation anomalies are specific to circular chains.
M_MED5 pre-registered experiment: the Alzheimer's amyloid cascade hypothesis dominates both justification and citation layers (circularity confirmed). Topology identified Lesne 2006 as a structural citation anomaly -- high citation rank, zero justification edges -- without reading the paper. The connected/disconnected contrast with M_MED4 (schizophrenia) is now a comparative structural observation, not a construction artifact.
IRDME analysis of the schizophrenia evidence chain found that the dopamine and NMDA hypotheses have zero structural contact across all three epistemic layers. They are not competing in the same evidence space - they are parallel research islands that have never formally engaged each other. Pre-registered experiment M_MED4_v1.
We mapped the opioid prescribing epidemic evidence chain (1980s-2010s) as a multilayer graph and pre-registered four structural hypotheses. Result: 3/4 CONFIRMED, 1/4 PARTIAL. pain_undertreated_claim is rank #1 in BOTH the justification layer and the citation layer -- the same structural circularity pattern found in antidepressants. porter_jick_letter (the 1980 NEJM 5-sentence letter misused as addiction-safety evidence) was identified as a citation anomaly by topology alone: high citation rank, peripheral justification rank. FPL gradient collapses in circular chains (r=0.14) vs healthy vaccine chain (r=0.75). Pre-registered.
We mapped the childhood vaccine evidence chain as a multilayer graph and compared its structural topology to the antidepressant circularity finding (M_MED1). The vaccine chain confirmed 4/4 hypotheses: the founding mechanism (adaptive immunity) is the justification hub, but empirical outcomes (clinical guidelines) dominate the citation layer. The two are different nodes -- structurally healthy. FPL gradient r=0.75 p=0.014 (statistically significant at n=8). Pre-registered. Contrast: in the antidepressant chain, the same founding assumption was top hub in all three layers.
IRDME applied to an 8-node epistemic graph of antidepressant research finds that the monoamine hypothesis is the #1 hub in BOTH the justification layer AND the citation-as-support layer. The founding assumption and the primary evidence are the same node. This is the structural signature of a self-referential evidence loop — detectable from topology alone, without reading a single paper.